Comparison of the protective effect of Withaferin-'A' and hydrocortisone against CCL4 induced hepatotoxicity in rats.

Sudhir, S; Budhiraja, R D

Sudhir, S; Budhiraja, R D.

Indian J Physiol Pharmacol ; 1992 Apr; 36(2): 127-9

Article in English | IMSEAR | ID: sea-107660

ABSTRACT

ABSTRACT

Protective effect of Withaferin-'A' against CCl4 induced hepatotoxicity has been assessed and the compound at 10 mg/kg dose was found to possess significant protective effect. A comparison of this protective effect with that of hydrocortisone showed it to be as effective as hydrocortisone dose per dose.

Subject(s)

Alkaline Phosphatase/blood; Animals; Blood Proteins/analysis; Carbon Tetrachloride/toxicity; Drug Interactions; Ergosterol/administration & dosage; Female; Hydrocortisone/administration & dosage; Liver/drug effects; Liver Diseases/chemically induced; Male; Rats

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Female / Male / Hydrocortisone / Carbon Tetrachloride / Blood Proteins / Drug Interactions / Alkaline Phosphatase / Ergosterol / Liver Language: English Journal: Indian J Physiol Pharmacol Year: 1992 Type: Article

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