Effects of some drugs on islet function in catfish.
Indian J Physiol Pharmacol
;
1984 Jul-Sep; 28(3): 200-5
Article
in English
| IMSEAR
| ID: sea-107693
ABSTRACT
Blood glucose variations and concomitant bioptical cytopathological changes in the pancreatic islets following treatment with certain drugs were studied in the catfish. Glucose loading produced a dose-related hyperglycemia, maximum within 3 hr, while alloxan caused a biphasic rise in glucose level without induction of permanent diabetes. Streptozotocin elicited a monophasic hyperglycemic state at a lower dose and biphasic response at higher doses. Glybenclamide produced hypoglycemia in normal and sham-operated fish; the depancreatized animals were unresponsive to this treatment. In all the cases, normoglycemic values were restituted within 4 days of the treatment. The beta-cells of the islets underwent varying histopathological changes with signs of regenerative activity. A depletion in heavy metal (zinc) in these cells was also evident after treatment with streptozotocin.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Blood Glucose
/
Female
/
Male
/
Islets of Langerhans
/
Glyburide
/
Streptozocin
/
Diabetes Mellitus, Experimental
/
Alloxan
/
Fishes
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1984
Type:
Article
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