Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats.
Indian J Physiol Pharmacol
;
1996 Apr; 40(2): 163-6
Article
in English
| IMSEAR
| ID: sea-107694
ABSTRACT
Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model. Intracerebroventricular (icv) administration of central inhibitory neurotransmitter, serotonin and its precursor, 5-hydroxytryptophan (5-HTP) attenuated the oedema volume and exudate protein content alongwith augmentation in pain threshold. On the contrary, cyproheptadine, a 5-HT-receptor antagonist and selective serotonin synthesis inhibitor, parachlorophenylalanine (PCPA) produced oedema augmenting and pro-nociceptive effects besides elevating the protein content of the exudate. Centrally administered histamine attenuated pedal oedema, nociception as well as protein concentration in oedema fluid. Cimetidine, an H2 histaminergic receptor blocker did not produce any significant effect on inflammation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Rats
/
Serotonin Antagonists
/
Time Factors
/
Nociceptors
/
Male
/
Histamine
/
Serotonin
/
Serotonin Receptor Agonists
/
Rats, Sprague-Dawley
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1996
Type:
Article
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