Effects of nitroxazepine on diastolic blood pressure in mild hypertensive patients--a short term clinical study.
Indian J Physiol Pharmacol
;
1995 Jul; 39(3): 293-5
Article
in English
| IMSEAR
| ID: sea-107778
ABSTRACT
In a double blind short term clinical study, nitroxazepine has been found to be superior over placebo in reducing the diastolic blood pressure in mild hypertensive patients. In short term open clinical trial design nitroxazepine (25 mg PO, HS) has been found to be superior and better tolerated than diazepam (5 mg PO, HS). In open clinical trial design, nitroxazepine (25 mg PO, HS) reduced the diastolic blood pressure to the target level (100 mm Hg and less) effectively controlling the uncontrolled hypertensive patients receiving maintenance dose of beta blockers. There was no such beneficial effect in patients receiving maintenance doses of other antihypertensive drugs (pilot study). Adverse drug reactions like disturbed sleep in one, uneasiness in 3, palpitation in one and dryness of mouth in one patient have been observed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Blood Pressure
/
Humans
/
Pilot Projects
/
Double-Blind Method
/
Adrenergic beta-Antagonists
/
Adult
/
Diazepam
/
Dibenzoxazepines
/
Hypertension
/
Antihypertensive Agents
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article
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