Effect of (Ala8,13,18)-magainin II amide on human trophoblast cells in vitro.
Indian J Physiol Pharmacol
;
2005 Jan; 49(1): 27-38
Article
in English
| IMSEAR
| ID: sea-107856
ABSTRACT
Magainins are cationic peptides with anti-bacterial and anti-tumor properties. The anti-nidatory function of a synthetic analogue of magainin, (Ala8,13,18)-magainin II amide, has earlier been reported, and it has been indicated that placental trophoblast cells could be a target of magainin resulting in its contragestational action. The aim of the present study was to examine the effect of (Ala8,13,18)-magainin II amide (100 ng/ml and 1000 ng/ml) on attachment efficiency, viability, differentiation in terms of hCG secretion and invasive function of isolated first trimester, human placental trophoblast cells grown on rat-tail collagen type-I matrix in primary cell culture. In the present experimental model, magainin was not found to affect human trophoblast cell functions in vitro.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Peptides
/
Trophoblasts
/
Female
/
Humans
/
Pregnancy
/
Cell Differentiation
/
Cell Survival
/
Cells, Cultured
/
Antimicrobial Cationic Peptides
/
Amides
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2005
Type:
Article
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