Studies on the toxic effects of streptolysin 'O': effect on the contractility of isolated and intact mammalian and amphibian heart.
Indian J Physiol Pharmacol
;
1976 Jul-Sep; 20(3): 164-7
Article
in English
| IMSEAR
| ID: sea-107858
ABSTRACT
The effect of streptolysin O (a streptococcal exotoxin) on the myocardial contractility of isolated and intact mammalian and amphibian heart has been investigated. Streptolysin O caused marked reduction or complete cessation of myocardial contractility of mammalian and amphibian heart both in vivo and in vitro. The effect of submaximal doses of streptolysin O on isolated atria was reversible after repeated washings and the myocardial depressant effect of streptolysin O on isolated atria was reversible after repeated washings and the myocardial depressant effect of streptolysin O was not antagonised by atropine. These observations would suggest that streptolysin O is cardiotoxic and may be involved in the causation of myocardial failure associated with acute rheumatic fever in man.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Rats
/
Atropine
/
Streptolysins
/
Cats
/
Atrial Function
/
Ventricular Function
/
Depression, Chemical
/
Dogs
/
Guinea Pigs
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1976
Type:
Article
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