Possible mechanism of hydrocortisone induced eosinopoenia.
Indian J Physiol Pharmacol
;
1979 Jul-Sep; 23(3): 219-24
Article
in English
| IMSEAR
| ID: sea-107928
ABSTRACT
Hydrocortisone (HC) injection in rabbits induced eosinopoenia (reduction in absolute eosinophil count) which could be successfully abolished by beta--adrenoceptor antagonists, a propranolol, sotalol, practolol and H 35/25 but not by alpha--adrenoceptor antagonist, phenoxybenzamine. Reserpine per se produced eosinopoenia followed by eosinophilia. However, reserpine pretreatment failed to abolish HC-induced eosinopoenia. It is suggested that the eosinopoenia is mediated through beta--adrenoceptors, which could not be differentiated into beta 1/beta 2--adrenoceptor subtypes as has been possible for other beta-adrenoceptor mediated responses.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Reserpine
/
Sympatholytics
/
Time Factors
/
Female
/
Male
/
Hydrocortisone
/
Eosinophils
/
Leukocyte Count
/
Leukopenia
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1979
Type:
Article
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