Involvement of dopaminergic mechanisms in racemate pentazocine induced stereotyped behaviour in rats.
Indian J Physiol Pharmacol
;
1996 Jul; 40(3): 271-3
Article
in English
| IMSEAR
| ID: sea-107944
ABSTRACT
Racemate pentazocine was found to induce stereotyped behaviour (SB) in rats. Pretreatment with haloperidol and alpha-methyl-p-tyrosine significantly antagonised dl-pentazocine induced SB. This indicates that dl-pentazocine induces SB by releasing dopamine (DA) from the nigrostriatal and mesolimbic dopaminergic neurones with resultant activation of the postsynaptic striatal and mesolimbic D2 DA receptors by the released DA. However, pretreatment with naloxone failed to significantly modify dl-pentazocine induced SB indicating thereby that opioid mechanisms are not involved in the DA releasing action of dl-pentazocine. Our findings are explained on the basis of recent reports that the d-isomer of pentazocine releases DA by stimulating sigma receptors located on the nigrostriatal and mesolimbic dopaminergic neurones.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pentazocine
/
Rats
/
Stereoisomerism
/
Stereotyped Behavior
/
Male
/
Dopamine
/
Alpha-Methyltyrosine
/
Analgesics, Opioid
/
Animals
/
Methyltyrosines
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1996
Type:
Article
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