Effect of nifedipine and dipyridamole on K+ and NA stimulated 45Ca-uptake into rabbit aortic strips.
Indian J Physiol Pharmacol
;
1993 Oct; 37(4): 342-4
Article
in English
| IMSEAR
| ID: sea-107964
ABSTRACT
The effect of dipyridamole (DPM), a purine nucleoside uptake inhibitor, on the K+ and noradrenaline (NA)-stimulated 45Ca-uptake into Rabbit aortic strips was studied and compared with that of nifedipine (NFD). DPM (10(-6) M) significantly (P < 0.02) inhibited 45Ca-uptake in aortic strips stimulated with K+ (10(-1) M). However, it had less significant effect on NA (10(-4) M)-stimulated 45Ca-uptake. The percentage inhibition was 80 and 57 in K+ and NA-stimulated 45Ca-uptake, respectively. Similarly, NFD (10(-7) M) caused significant (P < 0.01, P < 0.05) decrease in K+ (0.060 +/- 0.009) and NA (0.082 + 0.01, mM)-stimulated 45Ca-uptake. The percentage inhibition by NFD was 98 and 64 in K+ and NA-stimulated 45Ca-uptake, respectively. The results suggest that DPM inhibits Ca2+ influx occurring through Voltage Operated Calcium Channels (VOCCs) but it has little effect on Receptor Operated Calcium Channels (ROCCs).
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aorta, Thoracic
/
Potassium
/
Rabbits
/
Female
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Male
/
Nifedipine
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Calcium Channels
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Norepinephrine
/
Calcium
/
Dipyridamole
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1993
Type:
Article
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