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Effect of soman administration on beta-esterases in blood, liver microsomes and brain regions of rats.
Indian J Physiol Pharmacol ; 1992 Jul; 36(3): 197-200
Article in English | IMSEAR | ID: sea-107965
ABSTRACT
Activities of enzymes cholinesterase (ChE) and carboxylesterase (CaE) were assayed in serum, liver microsomes and three regions of brain, viz; cerebrum, cerebellum and brain stem (with mid brain) in male albino rats at 0.5 and 2 h periods after administration of 1/2 LD 50 dose of soman (0.22 mg/kg) intraperitoneally in olive oil as vehicle. At 0.5 h, in serum, ChE activity declined to 33% of its initial level whereas CaE activity was almost completely inhibited. However, in the liver microsomes at this period, ChE activity was greatly inhibited (18% of initial level) whereas CaE activity was nearly unaffected. At 2 h period, both the enzymes in the serum were almost completely inhibited. In the brain regions (excepting in cerebellum), both the enzymes were nearly similarly inhibited (by 55% to 65% of the initial level) at both the periods. The time related differential response of these two beta-esterases in acute soman intoxication probably occurred in the peripheral tissues like blood and liver but not in the CNS.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Soman / Brain / Brain Chemistry / Brain Stem / Male / Microsomes, Liver / Carboxylic Ester Hydrolases / Cerebellum / Cholinesterases Language: English Journal: Indian J Physiol Pharmacol Year: 1992 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Soman / Brain / Brain Chemistry / Brain Stem / Male / Microsomes, Liver / Carboxylic Ester Hydrolases / Cerebellum / Cholinesterases Language: English Journal: Indian J Physiol Pharmacol Year: 1992 Type: Article