Effect of intra amniotic saline and prostaglandin on fibrinolytic activity, prothrombin time and serum electrolytes -- a comparative study.

ABSTRACT

Effects of intra-amniotic instillation of hypertonic saline and prostaglandin F2 alpha for medical termination of pregnancy were studied. Fibrinolytic activity significantly increased at 4 hr and 24 hr after hypertonic saline but only at 24 hrs after prostaglandin. There was no significant change in prothrombin time after hypertonic saline but significant increase was observed after prostaglandin. In both the cases serum sodium level did not show any significant change. Serum potassium level significantly decreased at 24 hrs after hypertonic saline but no change was observed after prostaglandin.