Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils.
Indian J Physiol Pharmacol
;
2007 Jan-Mar; 51(1): 62-8
Article
in English
| IMSEAR
| ID: sea-108006
ABSTRACT
Involvement of p53 has been implicated in apoptosis induced cell death in ischemic reperfusion injury. In the present study, we have investigated neuroprotective potential of pifithrin-alpha, a p53 inhibitor in bilateral common carotid arteries occlusion (5 min) model of global cerebral ischemia in Mongolian gerbils. Gerbils were treated with pifithrin-alpha 3 mg/kg, ip. 30 min prior to occlusion. There was a significant increase in neurological symptoms and locomotor activity in ischemic animals as compared with the sham-operated animals. Increase in neurological symptoms and locomotor activity was attenuated by pifithrin-alpha 3 mg/ kg, ip. Significant increase in the number of the surviving neurons in the hippocampal CA1 pyramidal region was observed in ischemic animals treated with pifithrin-alpha 3 mg/kg, ip. This study demonstrates the neuroprotective effect of pifithrin-alpha in global cerebral ischemia in gerbils.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arterial Occlusive Diseases
/
Time Factors
/
Toluene
/
Male
/
Carotid Artery Diseases
/
Reperfusion Injury
/
Cell Survival
/
Brain Ischemia
/
Gerbillinae
/
Cell Death
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2007
Type:
Article
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