Effect of protein-calorie malnutrition on drug metabolising enzymes in rat liver.
Indian J Physiol Pharmacol
;
1987 Jul-Sep; 31(3): 170-7
Article
in English
| IMSEAR
| ID: sea-108007
ABSTRACT
Drugs are chiefly metabolised in the liver usually in two phases, viz. oxidation and conjugation. The present study was undertaken to investigate the effect of protein-calorie malnutrition (PCM), rehabilitation and effect of phenobarbitone on the hepatic drug metabolising enzymes in weanling albino rats, fed on a semisynthetic diet containing 18% or 0.5% protein. The two representative enzymes of oxidation and conjugation employed were aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase, respectively. The study revealed that PCM severely impairs oxidative drug metabolising enzyme but less so in conjugation stage. On refeeding 18% protein diet, drug metabolising enzymes returned to normal within 2-3 weeks. Phenobarbitone administration increased the activities of drug metabolising enzymes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Phenobarbital
/
Rats
/
Rats, Inbred Strains
/
Body Weight
/
Male
/
Protein-Energy Malnutrition
/
Diet
/
Glucosyltransferases
/
Aminopyrine N-Demethylase
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1987
Type:
Article
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