Reversal of paclitaxel induced neutropenia by Withania somnifera in mice.
Indian J Physiol Pharmacol
;
2001 Apr; 45(2): 253-7
Article
in English
| IMSEAR
| ID: sea-108011
ABSTRACT
The effect of aqueous extract of Withania somnifera (L. Solanaceae) was studied against paclitaxel induced neutropenia in mice. After paclitaxel 1 mg/kg, i.v. administration significant fall in total WBC and absolute neutrophil count was observed on day 3 and day 5. W. Somnifera (200 mg/kg, p.o.) per se produced significant increase in neutrophil counts. W. somnifera (200 mg/kg, p.o.) when administered for 4 days before paclitaxel treatment and continued for 12 days caused significant reversal of neutropenia of paclitaxel. The findings of the study suggest the potential of W. somnifera as an adjuvant during cancer chemotherapy for the prevention of bone marrow depression associated with anticancer drugs.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plants, Medicinal
/
Male
/
Plant Extracts
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
Paclitaxel
/
India
/
Animals
/
Phytotherapy
/
Mice
/
Neutropenia
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2001
Type:
Article
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