Effect of pre-treatment of some calcium channel blockers on catalepsy and stereotypic behaviour in rats.
Indian J Physiol Pharmacol
;
1996 Apr; 40(2): 159-62
Article
in English
| IMSEAR
| ID: sea-108017
ABSTRACT
Effect of pretreatment of intraperitoneally administered Ca-channel blockers Nifedipine (5, 10, 20 mg/kg). Verapamil (5, 10, 20 mg/kg) and Diltiazem (5, 10, 20 mg/kg) was studied on Haloperidol-induced catalepsy and Methamphetamine-induced stereotypy in albino rats. All these drugs reduced the onset of catalepsy, significantly increased the cataleptic score and delayed the onset and inhibited the Methamphetamine-induced stereotypy. The possible involvement of dopaminergic and adrenergic mechanisms and modification by Ca-channel blockers are discussed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Stereotyped Behavior
/
Female
/
Male
/
Calcium Channel Blockers
/
Diltiazem
/
Nifedipine
/
Verapamil
/
Catalepsy
/
Central Nervous System Depressants
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1996
Type:
Article
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