Pharmacological study of ulcerogenic action of antipyretic analgesic agents and their interaction with sodium salicylate.
Indian J Physiol Pharmacol
;
1983 Apr-Jun; 27(2): 151-6
Article
in English
| IMSEAR
| ID: sea-108074
ABSTRACT
The present work was undertaken to study and compare the gastric ulcerogenic action of analgesic antipyretic agents in guinea pigs. Their interaction with sodium salicylate was also studied. It was observed that aspirin, both microfined and ordinary, phenylbutazone, indomethacin and sodium salicylate were highly ulcerogenic in guinea pigs, while paracetamol and ibuprofen did not exhibit this action. It was also observed that sodium salicylate did not modify the ulcerogenic action of aspirin (both ordinary and microfined), phenylbutazone, ibuprofen and paracetamol but antagonized significantly the ulcerogenic action of indomethacin.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stomach Ulcer
/
Female
/
Male
/
Salicylates
/
Anti-Inflammatory Agents, Non-Steroidal
/
Salicylic Acid
/
Drug Interactions
/
Gastric Acid
/
Guinea Pigs
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1983
Type:
Article
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