Your browser doesn't support javascript.
loading
GABAergic agents modify imipramine analgesia.
Indian J Physiol Pharmacol ; 1996 Jan; 40(1): 95-7
Article in English | IMSEAR | ID: sea-108083
ABSTRACT
The influence of GABA agonists and antagonists on analgesic activity of imipramine (IMA, 20 mg/kg, ip) was studied using the hotplate method. Administration of GABAA receptor agonist muscimol (1 mg/kg, ip), GABAB receptor agonist baclofen (3 mg/kg, ip) or GABA-T inhibitor aminooxyacetic acid (25 mg/kg, ip) increased the analgesic effect of IMA. On the other hand pretreatment of GABAA receptor antagonist bicucukline (2 mg/kg ip), GABAB receptor antagonist delta-amino-n-valeric acid (50 mg/kg, ip) or GABA synthesis inhibitor thiosemicarbazide (50 mg/kg, ip) attenuated the IMA analgesia. These results suggest that the analgesic action of IMA may be mediated by functional alteration of a central GABAergic mechanism and/or subsequent stimulation of GABA receptors.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Male / Receptors, GABA-B / Receptors, GABA-A / GABA Antagonists / GABA Agonists / GABA Agents / Analgesics, Non-Narcotic / Enzyme Inhibitors / 4-Aminobutyrate Transaminase Language: English Journal: Indian J Physiol Pharmacol Year: 1996 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Male / Receptors, GABA-B / Receptors, GABA-A / GABA Antagonists / GABA Agonists / GABA Agents / Analgesics, Non-Narcotic / Enzyme Inhibitors / 4-Aminobutyrate Transaminase Language: English Journal: Indian J Physiol Pharmacol Year: 1996 Type: Article