GABAergic agents modify imipramine analgesia.
Indian J Physiol Pharmacol
;
1996 Jan; 40(1): 95-7
Article
in English
| IMSEAR
| ID: sea-108083
ABSTRACT
The influence of GABA agonists and antagonists on analgesic activity of imipramine (IMA, 20 mg/kg, ip) was studied using the hotplate method. Administration of GABAA receptor agonist muscimol (1 mg/kg, ip), GABAB receptor agonist baclofen (3 mg/kg, ip) or GABA-T inhibitor aminooxyacetic acid (25 mg/kg, ip) increased the analgesic effect of IMA. On the other hand pretreatment of GABAA receptor antagonist bicucukline (2 mg/kg ip), GABAB receptor antagonist delta-amino-n-valeric acid (50 mg/kg, ip) or GABA synthesis inhibitor thiosemicarbazide (50 mg/kg, ip) attenuated the IMA analgesia. These results suggest that the analgesic action of IMA may be mediated by functional alteration of a central GABAergic mechanism and/or subsequent stimulation of GABA receptors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Male
/
Receptors, GABA-B
/
Receptors, GABA-A
/
GABA Antagonists
/
GABA Agonists
/
GABA Agents
/
Analgesics, Non-Narcotic
/
Enzyme Inhibitors
/
4-Aminobutyrate Transaminase
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1996
Type:
Article
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