Effect of gold thiomalate on cell proliferation and collagen synthesis of synovial cells in culture.
Indian J Physiol Pharmacol
;
1987 Oct-Dec; 31(4): 245-9
Article
in English
| IMSEAR
| ID: sea-108084
ABSTRACT
Human synovial cells from cases of rheumatoid and osteoarthritis were cultured and at their 3-5 passages, were treated with gold thiomalate. At early-log phase gold thiomalate arrested the proliferation of cells. However, at confluent state shere was a slight proliferation of synovial cells. This was followed by an increase in prolyl hydroxylase, collagen and protein synthesis, indicating that gold salts directly stimulate the synovial cells.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arthritis, Rheumatoid
/
Synovial Membrane
/
Humans
/
Cell Division
/
Cells, Cultured
/
Collagen
/
Gold Sodium Thiomalate
/
Procollagen-Proline Dioxygenase
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1987
Type:
Article
Similar
MEDLINE
...
LILACS
LIS