Studies on the effect of penicillin, streptomycin and isonicotinic acid hydrazide on small intestinal oligosaccharidase.
Indian J Physiol Pharmacol
;
1975 Apr-Jun; 19(2): 71-5
Article
in English
| IMSEAR
| ID: sea-108085
ABSTRACT
Studies have been done on the effect of Penicillin, Streptomycin and Isonicotinic Acid hydrazide on small intestinal oligosaccharidase and it was observed that the drug penicillin inhibited the enzyme lactase and sucrase by 62.7% and 34.7% respectively, whereas I.N.H. inhibited the enzyme sucrase and maltase by 57.1% and 56.14% respectively. Streptomycin did not show any inhibitory effect on those enzymes. Lactose tolerance test showed impairment of lactose absorption in case of penicillin. Fasting serum sugar level was diminished both in penicillin and streptomycin and the absorption capacity was increased after oral administration of streptomycin.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Penicillins
/
Rabbits
/
Rats
/
Sucrase
/
Blood Glucose
/
Male
/
Streptomycin
/
Depression, Chemical
/
Disaccharidases
/
Galactosidases
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1975
Type:
Article
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