A dehydrogenase system to demonstrate oxidation of amphetamine and related compounds by rat brain homogenate.

Ghosh, S K; Guha, S R

Ghosh, S K; Guha, S R.

Indian J Physiol Pharmacol ; 1977 Apr-Jun; 21(2): 137-40

Article in English | IMSEAR | ID: sea-108115

ABSTRACT

ABSTRACT

Amphetamine, ephedrine, mescaline and chlorpromazine act as substrate for dehydrogenase system of rat brain homogenate. This system appears quite different from the usual deaminating process of these compounds, which required NADP and oxygen. The present system proceeds more rapidly in anaerobic condition.

Subject(s)

Amphetamine/metabolism; Animals; Brain/enzymology; Chlorpromazine/metabolism; Dextroamphetamine/metabolism; Ephedrine/metabolism; Formazans/metabolism; Mescaline/metabolism; Oxidation-Reduction; Oxidoreductases/metabolism; Oxygen/pharmacology; Rats; Tyramine/metabolism

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Oxidation-Reduction / Oxidoreductases / Oxygen / Rats / Brain / Tyramine / Chlorpromazine / Dextroamphetamine / Ephedrine / Formazans Language: English Journal: Indian J Physiol Pharmacol Year: 1977 Type: Article

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