Cerebral oedema and blood-brain and blood-CSF barriers in experimental brain trauma: effect of indomethacin-A prostaglandin synthetase inhibitor.
Indian J Physiol Pharmacol
;
1980 Apr-Jun; 24(2): 91-6
Article
in English
| IMSEAR
| ID: sea-108164
ABSTRACT
Cerebral oedema often occurs following trauma to the brain. Recently several biogenic amines have been suggested for their possible mediation in the pathophysiology of traumatic brain oedema. The present investigation indirectly indicates that prostaglandins of E series are also involved in the etiology of cerebral oedema, since administration of a potent PG synthetase inhibitor, indomethacin significantly diminished oedematous swelling of traumatised rat brain.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Prostaglandins E
/
Rats
/
Brain Edema
/
Brain Injuries
/
Female
/
Male
/
Blood-Brain Barrier
/
Cell Membrane Permeability
/
Cerebral Cortex
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1980
Type:
Article
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