Nicotine induced ovarian and uterine changes in albino mice.
Indian J Physiol Pharmacol
;
1998 Oct; 42(4): 503-8
Article
in English
| IMSEAR
| ID: sea-108203
ABSTRACT
Nicotine at the dose level of 0.3 mg/100 g body weight was administered to normal cycling mice for 15 days through oral and intraperitoneal routes. At autopsy on 16th day significant reduction in the ovarian and uterine weight was observed. Histological observations showed decrease in the number and size of Graafian follicles, corpora lutea and increase in the atretic follicles in the ovary. The uterus showed absence of endometrial glands, decrease in the height of myometrium, endometrium and its epithelial cells. The total cholesterol content of the ovary and uterus is increased whereas the protein content is decreased. This antagonistic action of nicotine to gonadotrophins is discussed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Ovary
/
Uterus
/
Female
/
Proteins
/
Cholesterol
/
Nicotinic Agonists
/
Animals
/
Mice
/
Nicotine
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1998
Type:
Article
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