Role of nitric oxide on insulin induced seizures in mice.
Indian J Physiol Pharmacol
;
1999 Jul; 43(3): 373-7
Article
in English
| IMSEAR
| ID: sea-108224
ABSTRACT
The role of nitric oxide (NO) on acute hypoglycemia-induced seizures in mice was investigated using insulin as the hypoglycemic agent. The NO precursor L-arginine in the doses of 150, 500 and 750 mg/kg exhibited a dose-dependent protective effect against seizures induced by 8 mu/kg insulin. The NO synthase inhibitor (L-NMMA) at the doses of 50 and 100 mg/kg potentiated the subconvulsive doses of insulin (2 mu/kg). The onset, duration, number of seizures and the mortality were noted in a 2 hr study period. The results of this study suggest than NO plays an important protective role in acute hypoglycemia induced seizures which are known to occur through the activation of NMDA receptors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arginine
/
Seizures
/
Male
/
Receptors, N-Methyl-D-Aspartate
/
Omega-N-Methylarginine
/
Nitric Oxide Donors
/
Dose-Response Relationship, Drug
/
Hypoglycemia
/
Insulin
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1999
Type:
Article
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