Aggravating action of clonidine on ethanol-induced gastric lesions: probable mechanism of action.
Indian J Physiol Pharmacol
;
1990 Oct; 34(4): 252-4
Article
in English
| IMSEAR
| ID: sea-108232
ABSTRACT
Large doses of the imidazoline alpha 2 adrenoreceptor agonist clonidine aggravate ethanol-induced gastric lesions. The alpha 2 adrenoceptor antagonist phentolamine, the opioid antagonist naloxone and the H2 antagonist cimetidine do not prevent this action of clonidine suggesting that it is not mediated by alpha 2, opioid or H2 receptors. Further, like clonidine, high doses of phentolamine and cimetidine aggravate gastric lesions per se, suggesting that all three may be acting at a common 'receptor' site, possibly the imidazoline-preferring receptor (IPR).
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phentolamine
/
Rats
/
Rats, Inbred Strains
/
Stomach Ulcer
/
Male
/
Receptors, Histamine H2
/
Cimetidine
/
Clonidine
/
Receptors, Opioid
/
Ethanol
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1990
Type:
Article
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