Protection of CCL4-induced liver damage in rats by some calcium channel blockers.
Indian J Physiol Pharmacol
;
1995 Jul; 39(3): 275-8
Article
in English
| IMSEAR
| ID: sea-108242
ABSTRACT
Liver necrosis was produced in rats by administering 3 doses o a mixture o carbon tetrachloide+olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels serun aspartate aminotrans ferase (AST), alanine aminotransferase (AIT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Nitrendipine, nimodipine and nisoldipine (1 mg/100 g of rat, ip) significantly reduced these elevated levels of AST, AIT and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in nitrendipine, nimodipine and nisoldipine pre-treated animals as observed macroscopically and histologically.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Aspartate Aminotransferases
/
Rats
/
Male
/
Carbon Tetrachloride Poisoning
/
Calcium Channel Blockers
/
Nimodipine
/
Nitrendipine
/
Nisoldipine
/
Rats, Wistar
/
Alanine Transaminase
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article
Similar
MEDLINE
...
LILACS
LIS