Reversal of changes of myocardial lipids by chronic administration of aspirin in isoproterenol-induced myocardial damage in rats.
Indian J Physiol Pharmacol
;
1992 Jan; 36(1): 47-50
Article
in English
| IMSEAR
| ID: sea-108302
ABSTRACT
The effect of aspirin on isoproterenol-induced changes related to myocardial damage was studied in rats. Rats were treated with aspirin (1.2 mg/100 g/day) orally, daily for a period of one month. Isoproterenol (20 mg/100 g, sc, twice at an interval of 24 hr) was administered. In isoproterenol treated rats marked increase in cholesterol, free fatty acids and triglycerides in both serum and heart were observed. The phospholipid level was lowered in heart with significant increase in serum in isoproterenol treatment. Serum LDL cholesterol was found to be increased with a significant decrease in the level of HDL cholesterol with enhanced level of lipid peroxides in heart. Aspirin showed marked reversal of these metabolic changes induced by isoproterenol.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phospholipids
/
Rats
/
Rats, Inbred Strains
/
Triglycerides
/
Male
/
Aspirin
/
Cholesterol
/
Lipid Metabolism
/
Fatty Acids, Nonesterified
/
Heart
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1992
Type:
Article
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