Antigen detection from urine of Kala-azar cases by latex agglutination tes.
Article
in English
| IMSEAR
| ID: sea-1084
ABSTRACT
A recently developed Latex agglutination method known as "KATEX" for detecting leishmanial antigen in urine of Kala-azar patients was evaluated on 97 Kala-azar cases and 35 controls in the department of Microbiology, Mymensingh Medical College during the period from March' 2004 to February' 2005. The method yielded sensitivity as 100% and 82.8% in 33 confirmed and 64 ICT positive cases respectively. Since 8.6% controls showed antigen positive results, so specificity of KATEX was calculated as 91.4%. KATEX methods for antigen detection in urine should be used as an early immuno-diagnostic test as it has yielded high sensitivity. But interpretation of a positive test must be made cautiously having correlation with clinical findings as because it becomes false positive in Kala-azar free person. Further elucidation of KATEX method including larger population from community giving particular emphasis on its prognostic use was strongly recommended.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Bangladesh
/
Leishmania donovani
/
Female
/
Humans
/
Male
/
Latex Fixation Tests
/
Child
/
Child, Preschool
/
Sensitivity and Specificity
/
Adolescent
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Year:
2008
Type:
Article
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