Effects of cimetidine combination with cyclophosphamide in transplanted murine tumors.
Indian J Physiol Pharmacol
;
1989 Jul-Sep; 33(3): 171-4
Article
in English
| IMSEAR
| ID: sea-108415
ABSTRACT
Studies were carried out on the combination of Cimetidine (CMTD) with Cytoxan (CTX) in three murine tumors. While the combination significantly potentiated the anticancer effect of CTX in L1210 leukemia, the results with P388 leukemia were not significantly different. The results with Lewis Lung Carcinoma showed a consistent reduction in the number of metastases. However, there was no consistent concomitant prolongation in survival. The host strain, biology of the tumour and the drug used in combination with CMTD might be some of the factors responsible for the varied response.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Male
/
Leukemia, Experimental
/
Leukemia L1210
/
Leukemia P388
/
Cimetidine
/
Cyclophosphamide
/
Drug Therapy, Combination
/
Lung Neoplasms
/
Animals
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1989
Type:
Article
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