Serum concentration and urinary excretion of ethambutol administered alone and in combination with isoniazid in patients of pulmonary tuberculosis.
Indian J Physiol Pharmacol
;
1985 Oct-Dec; 29(4): 223-6
Article
in English
| IMSEAR
| ID: sea-108417
ABSTRACT
Ethambutol (20 mg/kg) was administered orally to 10 patients of pulmonary tuberculosis for seven consecutive days at 8 a.m. after over night fast. On 7th day serum levels were measured at 2, 4, 6, 8 and 24 hr intervals and urinary excretion was estimated at 2, 4, 6 and 24 hr following ethambutol administration. Simultaneous administration of isoniazid (300 mg, orally) for next seven days to the same patients significantly raised the serum levels of ethambutol at 4, 6 and 8 hr and the cumulative per cent dose excreted was decreased significantly at 4, 6 and 24 hr. The serum levels and urinary elimination was not significantly different at 2 hr.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tuberculosis, Pulmonary
/
Female
/
Humans
/
Male
/
Administration, Oral
/
Adult
/
Ethambutol
/
Isoniazid
/
Middle Aged
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1985
Type:
Article
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