Spasmolytic activity of two synthetic anilide local anaesthetics.

Singh, G; Mishra, K C

Singh, G; Mishra, K C.

Indian J Physiol Pharmacol ; 1975 Jan-Mar; 19(1): 34-8

Article in English | IMSEAR | ID: sea-108466

ABSTRACT

ABSTRACT

Two basic anilides EA-7 and EA-8 were investigated for their antispasmodic activity against a variety of spasmogens on different tissues from different species of animals and comparison was made with lignocaine. EA-8 was found to be the most potent in this respect, followed by EA-7 and lignocaine. The antispasmodic potency does not correspond to their local anaesthetic potency. This suggests a direct depressant effect on tissues.

Subject(s)

Acetylcholine/antagonists & inhibitors; Anesthetics, Local/pharmacology; Anilides/pharmacology; Animals; Aorta/drug effects; Barium/antagonists & inhibitors; Depression, Chemical; Epinephrine/antagonists & inhibitors; Guinea Pigs; Histamine H1 Antagonists; Ileum/drug effects; Lidocaine/pharmacology; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Norepinephrine/antagonists & inhibitors; Rabbits; Rats; Trachea/drug effects

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Aorta / Rabbits / Rats / Trachea / Barium / Acetylcholine / Epinephrine / Norepinephrine / Depression, Chemical / Guinea Pigs Language: English Journal: Indian J Physiol Pharmacol Year: 1975 Type: Article

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