Effect of Septilin--a herbal preparation on pharmacokinetics of carbamazepine in rabbits.
Indian J Physiol Pharmacol
;
1998 Oct; 42(4): 527-32
Article
in English
| IMSEAR
| ID: sea-108499
ABSTRACT
The study was carried out in rabbits, to see the effects of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1/2a. t 1/2e. AUCo-alpha of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine were also reduced significantly in comparison to those of control rabbits after 7 days co-administration of Septilin. We conclude that Septilin decrease/hinder the absorption process of carbamazepine through an unknown mechanism.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Male
/
Carbamazepine
/
Plant Extracts
/
Anti-Inflammatory Agents, Non-Steroidal
/
Drug Interactions
/
Animals
/
Anticonvulsants
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1998
Type:
Article
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