Possible mechanism of endosulfan-induced enhancement of memory acquisition and retention in mice.
Indian J Physiol Pharmacol
;
1994 Apr; 38(2): 138-40
Article
in English
| IMSEAR
| ID: sea-108577
ABSTRACT
The effects of pre-training and post-training administration of endosulfan on retention of a step-down passive avoidance task was studied in mice. Endosulfan at doses of 1.0 mg/kg(ip) and 2.0 mg/kg(ip) enhanced memory acquisition and retention. This effect of endosulfan was possibly mediated by interaction with cholinergic neurotransmission, as scopolamine (0.5 mg/kg, ip) significantly antagonized the memory enhancing effects of endosulfan. Clonidine (0.05 mg/kg, ip) did not have any effect on enhancement of memory produced by endosulfan, thus indicating possibly no role of noradrenergic system.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Scopolamine
/
Avoidance Learning
/
Male
/
Clonidine
/
Synaptic Transmission
/
Dose-Response Relationship, Drug
/
Drug Interactions
/
Endosulfan
/
Injections, Intraperitoneal
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1994
Type:
Article
Similar
MEDLINE
...
LILACS
LIS