Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness.
Indian J Physiol Pharmacol
;
1995 Jul; 39(3): 299-301
Article
in English
| IMSEAR
| ID: sea-108583
ABSTRACT
Intracerebral microinjections of gamma amino butyric acid were given bilaterally at the medial preoptic area (mPOA) to determine the possible role of this neurotransmitter in the genesis and regulation of sleep-wakefulness. GABA (50 micrograms/0.2 microliters) when administered through chronically implanted cannulae in free moving rats, did not produce any significant alterations in sleep-wakefulness. This may be attributed either to the non-involvement of GABA at the level of mPOA in the regulation of sleep, or to other factors like the low dose and rapid breakdown of the injected drug.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Preoptic Area
/
Rats
/
Sleep
/
Wakefulness
/
Male
/
Rats, Wistar
/
Electroencephalography
/
Gamma-Aminobutyric Acid
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article
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