Effect of verapamil on gastric acid secretion and ulceration by pyloric-ligation and aspirin in albino rats.
Indian J Physiol Pharmacol
;
1989 Apr-Jun; 33(2): 113-7
Article
in English
| IMSEAR
| ID: sea-108642
ABSTRACT
Verapamil at doses 5, 10, 20 and 40 mg/kg, intraperitoneally (ip) and 40 mg/kg, orally reduced incidence of ulceration by Pyloric-ligation. Similarly verapamil inhibited aspirin-induced ulceration at a dose 40 mg/kg, orally and ip. Effect of verapamil on gastric acid secretion was also studied. At low dose it increased acid secretion significantly (5 mg/kg, ip) and at high dose (40 mg kg, ip and orally) it significantly decreased volume of secretion. This indicates that reduction of acid secretion contributes little to the antiulcer activity of verapamil because antiulcer effect was seen even at doses which did not decrease acid secretion.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pylorus
/
Rats
/
Stomach Ulcer
/
Verapamil
/
Aspirin
/
Gastric Acid
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1989
Type:
Article
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