Effect of drugs influencing central 5-hydroxytryptamine mechanisms on amantadine-induced stereotyped behaviour in the rat.
Indian J Physiol Pharmacol
;
1983 Jan-Mar; 27(1): 19-24
Article
in English
| IMSEAR
| ID: sea-108667
ABSTRACT
Pretreatment with L-tryptophan, a precursor of 5-HT, was found to decrease the intensity of stereotyped behaviour induced by amantadine, while methysergide, a 5-HT antagonist, was found to increase the intensity of amantadine-induced stereotypy. These results suggest that the intensity of amantadine-induced stereotypy depends on the balance between central dopamine and 5-HT systems and that the central 5-HT systems may have an opposing, tonic effect upon central dopamine systems involved in the mediation of stereotypy. In contrast to L-tryptophan, however, pretreatment with quipazine, a 5-HT agonist, and clomipramine, a selective 5-HT neuronal reuptake blocker, was found to potentiate the stereotyped behaviour induced by amantadine.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Quipazine
/
Rats
/
Stereotyped Behavior
/
Tryptophan
/
Humans
/
Male
/
Amantadine
/
Serotonin
/
Clomipramine
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1983
Type:
Article
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