Central modulation of Brewer's yeast-induced peripheral inflammation by neuropeptides bradykinin and substance P.
Indian J Physiol Pharmacol
;
1996 Oct; 40(4): 367-71
Article
in English
| IMSEAR
| ID: sea-108697
ABSTRACT
Possible modulation of the Brewer's yeast-induced peripheral inflammation by two central neuropeptides, bradykinin and substance P (SP), was investigated in rats. Centrally administered bradykinin significantly increased pedal oedema and pain threshold whereas, SP produced significant augmentation of oedema volume and nociception. The results of the present study indicate that central bradykinin exerts pro-inflammatory and analgesic effects whereas, central SP exerts pro-inflammatory and pro-nociceptive effects on Brewer's yeast-induced peripheral inflammation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Rats
/
Saccharomyces cerevisiae
/
Male
/
Bradykinin
/
Substance P
/
Rats, Sprague-Dawley
/
Edema
/
Analgesics
/
Inflammation
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1996
Type:
Article
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