Synthesis and in vivo hypoglycemic screening studies on some life essential metal complexes of oral antidiabetic [N-(p-tolylsulphonyl)-N'-n butyl-urea] (tolbutamide).
Indian J Physiol Pharmacol
;
1995 Apr; 39(2): 166-8
Article
in English
| IMSEAR
| ID: sea-108715
ABSTRACT
Present communication deals with the synthesis of complexes of [N-(p-tolylsulphonyl)-N'-n butyl-urea], with certain transition metals viz. Cu(II), Zn(II), Fe(II) and Cd(II). Structures of all the complexes have been established on the basis of their consistent elemental and spectral analysis. Also, it reports their in vivo hypoglycemic screening on albino rats. Out of all the complexes studied, Zn-Tolbutamide complex could be recommended as more potent hypoglycemic agent in lieu of tolbutamide alone.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Spectrophotometry, Infrared
/
Tolbutamide
/
Zinc
/
Cadmium
/
Administration, Oral
/
Copper
/
Drug Synergism
/
Hypoglycemia
/
Iron
Type of study:
Diagnostic study
/
Screening study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article
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