Uterotropic effect of clofibrate and phenylbutazone in immature female rats.

Chandra, D; Thulasimany, M; Biswas, A R

Chandra, D; Thulasimany, M; Biswas, A R.

Indian J Physiol Pharmacol ; 1982 Apr-Jun; 26(2): 147-51

Article in English | IMSEAR | ID: sea-108729

ABSTRACT

ABSTRACT

The uterotropic effect of clofibrate and phenylbutazone was studied in immature female rats. A significant increase in the uterine wet weight was observed following clofibrate and phenylbutazone administration. Clofibrate but not phenylbutazone synergized with the uterotropic effect of ethinyl-oestradiol. Phenylbutazone pretreatment significantly decreased the pentobarbitone sleeping time. The uterotropic effect of clofibrate and phenylbutazone might involve displacement of 17-beta oestradiol (or ethinyl oestradiol) from plasma albumin binding sites in rats.

Subject(s)

Animals; Clofibrate/pharmacology; Drug Synergism; Estrogens; Ethinyl Estradiol/pharmacology; Female; Organ Size/drug effects; Pentobarbital/antagonists & inhibitors; Phenylbutazone/pharmacology; Rats; Sleep/drug effects; Uterus/drug effects

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Organ Size / Pentobarbital / Rats / Sleep / Uterus / Female / Phenylbutazone / Clofibrate / Drug Synergism / Estrogens Language: English Journal: Indian J Physiol Pharmacol Year: 1982 Type: Article

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