Post traumatic epilepsy: a review of scientific evidence.
Indian J Physiol Pharmacol
;
2006 Jan-Mar; 50(1): 7-16
Article
in English
| IMSEAR
| ID: sea-108767
ABSTRACT
Post traumatic epilepsy is the development of recurrent seizures following head trauma and has a high clinical relevance. Several risk factors including some genetic factors increase the susceptibility of post traumatic epilepsy. The precise mechanisms of epileptogenesis in post-traumatic epilepsy are still poorly understood. Many structural, physiologic and biochemical changes in the brain may account for epileptogenesis. The reactive oxygen species (ROS), especially *OH and excitotoxicity are primarily involved. Antioxidants, like tocopherol, antiepileptic drug zonisamide, condensed tannins, melatonin, adenosine, trans-resveratrol, and some other agents have been proposed to prevent epileptogenic focus formation. The review also discusses various aspects of post traumatic epilepsy, mechanisms of epileptogenesis, and clinical implications.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Brain Chemistry
/
Humans
/
Epilepsy, Post-Traumatic
/
Reactive Oxygen Species
/
Animals
/
Anticonvulsants
/
Antioxidants
Type of study:
Risk factors
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2006
Type:
Article
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