Protective effect of clonidine against the cardiotoxic effects of ouabain in cat.
Indian J Physiol Pharmacol
;
1990 Jul; 34(3): 183-6
Article
in English
| IMSEAR
| ID: sea-108784
ABSTRACT
Cardiac arrhythmias and cardiac arrest were induced in pentobarbitone anaesthetised cats by slow intravenous infusion of ouabain. The dose of ouabain required for the induction of the stages of arrhythmias and cardiac arrest and the maximum pressor effect induced by ouabain were assessed in control and clonidine pretreated cats. Clonidine caused significant delay in the onset of cardiotonic effects of ouabain and inhibition of the maximum pressor effect of ouabain. The inhibition of cardiotoxic and pressor effects of ouabain may be the result of clonidine's effect on the neural components of ouabain action.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ouabain
/
Arrhythmias, Cardiac
/
Blood Pressure
/
Female
/
Male
/
Cats
/
Clonidine
/
Heart Arrest
/
Heart Diseases
/
Hemodynamics
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1990
Type:
Article
Similar
MEDLINE
...
LILACS
LIS