Interaction of pargyline with tolbutamide in rabbits.
Indian J Physiol Pharmacol
;
1995 Jan; 39(1): 71-3
Article
in English
| IMSEAR
| ID: sea-108795
ABSTRACT
Acute treatment of rabbits with pargyline (50 mg/kg, ip, 30 min before tolbutamide) significantly increased the elimination half life and AUC0-->infinity of tolbutamide resulting in prolonged hypoglycaemia. Similar treatment also prolonged the half life of antipyrine which is used as model drug to indicate hepatic microsomal enzyme activity in vivo confirming that pargyline treatment delayed the elimination of tolbutamide in rabbits by inhibiting its hepatic metabolism.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pargyline
/
Rabbits
/
Tolbutamide
/
Blood Glucose
/
Female
/
Male
/
Microsomes, Liver
/
Antipyrine
/
Drug Interactions
/
Half-Life
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article
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