Effect of ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on ethanol induced hypoproteinemia and hyperlipidemia in rats.
Indian J Physiol Pharmacol
;
2005 Oct-Dec; 49(4): 422-6
Article
in English
| IMSEAR
| ID: sea-108797
ABSTRACT
We studied effect of exogenous ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on serum lipids and proteins in experimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6 g/kg/day) for 28 days. Both preventive and curative options were studied. Percentage increase in body weight was significantly lower in ethanol treated rats. Ethanol significantly (P<0.05) increased cholesterol, triglycerides and LDL, and decreased protein, albumin and AG ratio in serum. Ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate exhibited an ability to counteract the alcohol-induced changes in the body weight and biochemical parameters in preventive and therapeutic models in varying degree. Antioxidants showed better effect.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phosphatidylcholines
/
Ascorbic Acid
/
Rats
/
Body Weight
/
Male
/
Central Nervous System Depressants
/
Rats, Wistar
/
Alpha-Tocopherol
/
Dipeptides
/
Ethanol
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2005
Type:
Article
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