The reversal by metoclopramide of apomorphine-induced inhibition of responses to stimulation of the cardioaccelerator nerves in the cat.
Indian J Physiol Pharmacol
;
1984 Jan-Mar; 28(1): 15-20
Article
in English
| IMSEAR
| ID: sea-108911
ABSTRACT
The effect of metoclopramide on presynaptic dopamine receptors was investigated in the cat cardioaccelerator nerve preparation. Metoclopramide, a substituted benzamide derivative, antagonized inhibitory action of apomorphine on positive chronotropic responses induced by sympathetic nerve stimulation in cat hearts, in vivo. Neither phentolamine, an alpha-adrenergic blocking agent, nor indomethacin a prostaglandin synthesis inhibitor, antagonized the effect of apomorphine. Apomorphine did not alter the positive chronotropic effects of intravenously administered noradrenaline. Metoclopramide potentiated stimulation-induced positive chronotropic responses. These results suggest that metoclopramide blocks the presynaptic dopamine receptors at the cat heart.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phentolamine
/
Sympathetic Nervous System
/
Female
/
Male
/
Apomorphine
/
Norepinephrine
/
Cats
/
Indomethacin
/
Receptors, Dopamine
/
Electric Stimulation
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1984
Type:
Article
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