Increased glycated hemoglobin level in non-diabetic nephrotic children is associated with oxidative stress.
Indian J Physiol Pharmacol
;
2007 Apr-Jun; 51(2): 153-9
Article
in English
| IMSEAR
| ID: sea-108931
ABSTRACT
Glycation and lipid peroxidation are spontaneous reactions believed to contribute to the pathogenesis of nephrotic syndrome. Possible interrelations of glycated hemoglobin with reduced glutathione and malondialdehyde were evaluated in nephrotic syndrome patients. Eighteen nephrotic syndrome patients and 15 healthy controls were enrolled for this study. Glycated hemoglobin, reduced glutathione, malondialdehyde and fasting glucose were analyzed for their correlation in both the groups. In nephrotic syndrome patients, while glycated hemoglobin and malondialdehyde levels were found to be significantly increased, glutathione levels decreased significantly when compared with controls. Glycated hemoglobin was found to have a significant positive correlation with malondialdehyde and a negative correlation with glutathione. Erythrocytes depleted of glutathione, by pre-treatment with 1-chloro-2, 4-dinitrobenezene, were found to have higher glycated hemoglobin levels when compared with erythrocytes incubated with glucose alone. These data suggest that glycated hemoglobin levels are closely associated with malondialdehyde and glutathione in nephrotic syndrome patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Glycated Hemoglobin
/
Linear Models
/
Child
/
Child, Preschool
/
Adolescent
/
Oxidative Stress
/
Glutathione
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2007
Type:
Article
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