Role of 5-HT on increased permeability of blood-brain barrier under heat stress.
Indian J Physiol Pharmacol
;
1984 Oct-Dec; 28(4): 259-67
Article
in English
| IMSEAR
| ID: sea-108971
ABSTRACT
Exposure of young rats (9-10 wks) to chronic summer heat (36 degrees C) or acute heat (38 degrees C 4hr) increased the BBB permeability to Evans blue albumin complex (MW 68,000) and 131I-sodium (MW 154) in different brain regions which correlated well with the increased level of 5-HT in plasma and brain. This increased permeability of BBB and the increased 5-HT level were prevented by pretreatment with p-CPA, indomethacin and diazepam. Cyproheptadine and vinblastine pretreatment however, prevented only the increased permeability of BBB, the plasma and brain 5-HT level continued to remain high. These results indicate a probable role of 5-HT as one of the factors leading to the increased permeability of BBB in young rats following heat stress.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Permeability
/
Rats
/
Vinblastine
/
Brain Chemistry
/
Female
/
Male
/
Blood-Brain Barrier
/
Serotonin
/
Indomethacin
/
Fenclonine
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1984
Type:
Article
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