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Effect of country liquor (Indian alcoholic beverage) on carcinogen activating and detoxifying enzymes.
Indian J Physiol Pharmacol ; 1993 Jan; 37(1): 85-7
Article in English | IMSEAR | ID: sea-108984
ABSTRACT
The levels of some important drug activating and detoxyfying enzymes were estimated in the livers of Swiss mice treated with a local brand of country liquor. Following liquor ingestion in male mice elevated levels of hepatic cytochrome P-450 were observed, while female mice did not show this. Cytochrome b5 levels remained unchanged. Similarly in male mice, increase in hepatic reduced glutathione levels were obtained while in female mice, decrease in this was observed. The activity of glutathione S-transferase was not changed. It is suggested that the increases in cytochrome P-450 and in hepatic reduced glutathione may be important determinants in carcinogenecity of the country liquors.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Male / Microsomes, Liver / Cytochromes b5 / Sex Factors / Cytochrome P-450 Enzyme System / Alcoholic Beverages / Glutathione / Glutathione Transferase / India Country/Region as subject: Asia Language: English Journal: Indian J Physiol Pharmacol Year: 1993 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Male / Microsomes, Liver / Cytochromes b5 / Sex Factors / Cytochrome P-450 Enzyme System / Alcoholic Beverages / Glutathione / Glutathione Transferase / India Country/Region as subject: Asia Language: English Journal: Indian J Physiol Pharmacol Year: 1993 Type: Article