Influence of calcium removal from bath solution on isolated rat duodenum contractions.
Indian J Physiol Pharmacol
;
1992 Jul; 36(3): 181-4
Article
in English
| IMSEAR
| ID: sea-108988
ABSTRACT
In this study whether extracellular Ca++ is essential to produce an increase of tension of isolated rat duodenum by ACh, 5-HT, AVP and KCl-, was examined. KCl- and AVP-evoked contractions were almost totally prevented by Ca++ removal from bath solution. The increase of tension of isolated duodenum caused by ACh or 5-HT was totally prevented after adding nifedipine, a Ca++ channel blocker, into Ca free solution. Our results suggest that ACh or 5-HT utilizes intracellular as well as extracellular sources of Ca++ to produce contraction in rat duodenum, whereas AVP-or KCl evoked contraction was mainly due to influx of Ca from extracellular sources.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Potassium Chloride
/
Rats
/
Arginine Vasopressin
/
Nifedipine
/
Acetylcholine
/
Serotonin
/
Calcium
/
Duodenum
/
Animals
/
Muscle Contraction
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1992
Type:
Article
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