A comparative clinical trial of albendazole versus metronidazole in giardiasis.
Indian Pediatr
;
1995 Mar; 32(3): 291-4
Article
in English
| IMSEAR
| ID: sea-10912
ABSTRACT
The adverse effects and treatment failures to some of the currently recommended drugs for giardia infection have given rise to the need for alternative antigiardial agents. In an open, randomized parallel group study, the safety and efficacy of albendazole was compared with that of metronidazole for the treatment of giardiasis in children. Sixty two children aged between 2-12 years were randomized to receive either albendazole suspension 400 mg daily for 5 days or metronidazole suspension 7.5 mg/kg thrice daily for 5 days. The mean days required for cure, as evident by absence of cysts and/or trophozoites in the stool specimen, was 3.7 + 1.4 and 4.5 + 1.1 days, respectively for children on albendazole and metronidazole therapy. Six children on metronidazole therapy developed anorexia 2 to 4 days after the treatment. Albendazole proved as effective as metronidazole in the treatment of giardia infection in children with the added advantage of absence of anorexia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Anorexia
/
Albendazole
/
Child
/
Child, Preschool
/
Giardiasis
/
Metronidazole
/
Antiprotozoal Agents
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian Pediatr
Year:
1995
Type:
Article
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