Homing of radiolabelled recombinant interleukin-2 activated natural killer cells and their efficacy in adoptive immunotherapy against murine fibrosarcoma.
J Biosci
;
2007 Dec; 32(7): 1299-305
Article
in English
| IMSEAR
| ID: sea-111077
ABSTRACT
Natural killer (NK) cells are spontaneously cytotoxic against tumour target cells. Their number was found to be four times more in the spleen of tumour-bearing Swiss albino mice. After activation with recombinant interleukin-2 (rIL-2), NK cells were tested and found to seek out the tumour site when injected intravenously in tumour-bearing mice. Their potential for fighting tumours in vivo was further seen following adoptive transfer of rIL-2 activated NK (A-NK) cells in tumour-bearing mice. After surgical removal of tumour load, adoptive transfer of A-NK cells inhibited tumour recurrence in 92.3%cases, thereby suggesting the use of this protocol for therapeutic purposes to obtain a better outcome.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Recurrence
/
Time Factors
/
Killer Cells, Natural
/
Immunotherapy, Adoptive
/
Interleukin-2
/
Fibrosarcoma
/
Animals
/
Mice
Type of study:
Practice guideline
Language:
English
Journal:
J Biosci
Year:
2007
Type:
Article
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