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Type 2 diabetes mellitus: phylogenetic motifs for predicting protein functional sites.
J Biosci ; 2007 Aug; 32(5): 999-1004
Article in English | IMSEAR | ID: sea-111147
ABSTRACT
Diabetes mellitus, commonly referred to as diabetes, is a medical condition associated with abnormally high levels of glucose (or sugar) in the blood. Keeping this view, we demonstrate the phylogenetic motifs (PMs) identification in type 2 diabetes mellitus very likely corresponding to protein functional sites. In this article, we have identified PMs for all the candidate genes for type 2 diabetes mellitus. Glycine 310 remains conserved for glucokinase and potassium channel KCNJ11. Isoleucine 137 was conserved for insulin receptor and regulatory subunit of a phosphorylating enzyme. Whereas residues valine, leucine, methionine were highly conserved for insulin receptor.Occurrence of proline was very high for calpain 10 gene and glucose transporter.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phylogeny / Binding Sites / Humans / Proteins / Predictive Value of Tests / Sequence Homology, Amino Acid / Conserved Sequence / Catalytic Domain / Sequence Analysis, Protein / Amino Acid Motifs Type of study: Prognostic study Language: English Journal: J Biosci Year: 2007 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phylogeny / Binding Sites / Humans / Proteins / Predictive Value of Tests / Sequence Homology, Amino Acid / Conserved Sequence / Catalytic Domain / Sequence Analysis, Protein / Amino Acid Motifs Type of study: Prognostic study Language: English Journal: J Biosci Year: 2007 Type: Article