Type 2 diabetes mellitus: phylogenetic motifs for predicting protein functional sites.
J Biosci
;
2007 Aug; 32(5): 999-1004
Article
in English
| IMSEAR
| ID: sea-111147
ABSTRACT
Diabetes mellitus, commonly referred to as diabetes, is a medical condition associated with abnormally high levels of glucose (or sugar) in the blood. Keeping this view, we demonstrate the phylogenetic motifs (PMs) identification in type 2 diabetes mellitus very likely corresponding to protein functional sites. In this article, we have identified PMs for all the candidate genes for type 2 diabetes mellitus. Glycine 310 remains conserved for glucokinase and potassium channel KCNJ11. Isoleucine 137 was conserved for insulin receptor and regulatory subunit of a phosphorylating enzyme. Whereas residues valine, leucine, methionine were highly conserved for insulin receptor.Occurrence of proline was very high for calpain 10 gene and glucose transporter.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phylogeny
/
Binding Sites
/
Humans
/
Proteins
/
Predictive Value of Tests
/
Sequence Homology, Amino Acid
/
Conserved Sequence
/
Catalytic Domain
/
Sequence Analysis, Protein
/
Amino Acid Motifs
Type of study:
Prognostic study
Language:
English
Journal:
J Biosci
Year:
2007
Type:
Article
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